How can I identify a disorder using the Diagnosis API based on symptoms and test results like CBC (anemia), TSH, and CMP?

To identify the potential health problem causing your fatigue based on the suggested lab tests (CBC, TSH, CMP), we can follow a systematic approach: Complete Blood Count (CBC) – Rule Out Anemia Fatigue is a classic symptom of anemia. Key CBC findings: Low Hemoglobin (Hb) & Hematocrit (Hct) → Confirms anemia. Microcytic anemia (low MCV): Iron deficiency (check ferritin, TIBC, serum iron) Chronic disease anemia (elevated ferritin) Macrocytic anemia (high MCV): Vitamin B12 or folate deficiency (check B12, folate levels) Normocytic anemia (normal MCV): Chronic kidney disease (CKD) → Check creatinine (CMP) Hemolysis or bone marrow disorder → Check reticulocyte count Thyroid-Stimulating Hormone (TSH) – Rule Out Thyroid Dysfunction High TSH + Low Free T4 → Hypothyroidism (common cause of fatigue) Low TSH + High Free T4 → Hyperthyroidism (can also cause fatigue) Normal TSH → Thyroid likely not the cause Comprehensive Metabolic Panel (CMP) – Check Electrolytes, Kidney, Liver, Glucose Electrolyte imbalances: Low sodium (hyponatremia) → Could indicate adrenal insufficiency (check cortisol) Low potassium (hypokalemia) → Could suggest aldosterone issues High calcium (hypercalcemia) → Could indicate hyperparathyroidism Kidney function: High creatinine/BUN → Possible CKD (fatigue due to uremia) Liver function: Elevated AST/ALT → Liver disease (fatigue is common) Glucose abnormalities: High glucose → Diabetes (fatigue due to poor glucose control) Low glucose → Hypoglycemia (can cause fatigue) Next Steps if Initial Tests Are Normal If CBC, TSH, and CMP are normal, consider: Vitamin D deficiency (check 25-OH Vitamin D) Sleep disorders (sleep apnea, insomnia) Chronic fatigue syndrome (diagnosis of exclusion) Depression or anxiety (mental health screening) Adrenal insufficiency (check morning cortisol & ACTH) Chronic infections (EBV, Lyme disease, HIV) Summary of Likely Causes Based on Initial Tests Test Possible Issue Next Steps CBC (Low Hb) Anemia (iron/B12/folate deficiency, CKD) Check ferritin, B12, folate, reticulocyte count TSH (High) Hypothyroidism Check Free T4, thyroid antibodies CMP (Abnormal electrolytes/kidney) Electrolyte imbalance, CKD, liver disease Further workup based on specific abnormality Would you like help interpreting your specific lab results? If you enter them as parameters for AI-driven SmrtX Diagnosis API, it can give a more precise analysis.

Apr 1, 2025 - 22:51

How can I identify a disorder using the Diagnosis API based on symptoms and test results like CBC (anemia), TSH, and CMP?

To identify the potential health problem causing your fatigue based on the suggested lab tests (CBC, TSH, CMP), we can follow a systematic approach:

Complete Blood Count (CBC) – Rule Out Anemia Fatigue is a classic symptom of anemia. Key CBC findings:

Low Hemoglobin (Hb) & Hematocrit (Hct) → Confirms anemia.
Microcytic anemia (low MCV):
Iron deficiency (check ferritin, TIBC, serum iron)
Chronic disease anemia (elevated ferritin)
Macrocytic anemia (high MCV):
Vitamin B12 or folate deficiency (check B12, folate levels)
Normocytic anemia (normal MCV):
Chronic kidney disease (CKD) → Check creatinine (CMP)
Hemolysis or bone marrow disorder → Check reticulocyte count

Thyroid-Stimulating Hormone (TSH) – Rule Out Thyroid Dysfunction High TSH + Low Free T4 → Hypothyroidism (common cause of fatigue) Low TSH + High Free T4 → Hyperthyroidism (can also cause fatigue) Normal TSH → Thyroid likely not the cause
Comprehensive Metabolic Panel (CMP) – Check Electrolytes, Kidney, Liver, Glucose Electrolyte imbalances: Low sodium (hyponatremia) → Could indicate adrenal insufficiency (check cortisol) Low potassium (hypokalemia) → Could suggest aldosterone issues High calcium (hypercalcemia) → Could indicate hyperparathyroidism Kidney function: High creatinine/BUN → Possible CKD (fatigue due to uremia) Liver function: Elevated AST/ALT → Liver disease (fatigue is common) Glucose abnormalities: High glucose → Diabetes (fatigue due to poor glucose control) Low glucose → Hypoglycemia (can cause fatigue) Next Steps if Initial Tests Are Normal If CBC, TSH, and CMP are normal, consider:

Vitamin D deficiency (check 25-OH Vitamin D)
Sleep disorders (sleep apnea, insomnia)
Chronic fatigue syndrome (diagnosis of exclusion)
Depression or anxiety (mental health screening)
Adrenal insufficiency (check morning cortisol & ACTH)
Chronic infections (EBV, Lyme disease, HIV)
Summary of Likely Causes Based on Initial Tests
Test Possible Issue Next Steps
CBC (Low Hb) Anemia (iron/B12/folate deficiency, CKD) Check ferritin, B12, folate, reticulocyte count
TSH (High) Hypothyroidism Check Free T4, thyroid antibodies
CMP (Abnormal electrolytes/kidney) Electrolyte imbalance, CKD, liver disease Further workup based on specific abnormality
Would you like help interpreting your specific lab results? If you enter them as parameters for AI-driven SmrtX Diagnosis API, it can give a more precise analysis.